Clot Lysis Induced by a Monoclonal Antibody Against a2-Plasmin Inhibitor
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چکیده
A monoclonal antibody (MoAb) to a -plasmin inhibitor designated JTPI-1 inhibited antiplasmin activity by interfering with formation of a2-plasmin inhibitor (a2-Pl)-plasmin complex. With this MoAb, we observed plasma clot lysis in vitro and evaluated the potential of JTPI-1 to serve as a new therapeutic agent for thrombolysis. After adding lThl labeled fibrinogen to plasma, clots were made by adding thrombin and calcium and were then resuspended in normal plasma containing various concentrations of JTPI-1 . The presence of JTPI-1 enhanced release of the soluble ‘ 1-labeled fibrin degradation fragment from the clots in a dose-dependent manner. With tissue plasminogen activator (t-PA)-depleted plasma, we showed that induction of clot lysis by JTPI-1 was dependent on fibrin-
منابع مشابه
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تاریخ انتشار 2005